An interesting approach to the healing of various injuries as "regenerative medicine" or "tissue engineering" has been the use of platelet-rich plasma (PRP), alone or in combination with stem cells.
PRP has recently announced, when it was reported that Hines Ward, Pittsburgh Steele the big star of the recipient has received treatment for an injury before the Super Bowl.
Consequently, the PRP, it was time for a certoNon, Sortesurtout in uur heart to accelerate the cure of diseases such as tendonitis, ligament strains, muscle strains, arthritis, synovitis (inflammation of the joints) and cartilage injuries.
Platelet-rich plasma is used as a graft matrix, often referred to as autologous tissue. The platelet-rich plasma (PRP), the matrix is defined as an autologous tissue from the integration of agricultural and / or cells Autologhe undifferentiated matrix in which the design is on theBasis of the receptor and the regeneration of tissues. "(Crane D, Everts PAM. The practice of pain. 2008, January / February: 12-26) 2008)
Why is it so useful is that PRP platelets, a normal constituent of blood cells, growth factors, the growth of tissues. In particular, PRP stimulates the growth of collagen which principaleth part of the connective tissue such as cartilage and tendons. Questi factors include transforming growth factor-B (TGF-B), Fibroblasten-growth, growth factor platelet-derived growth factor, epidermal, growth factor, connective tissue growth factor, vascular endothelial.
These growth factors recruit undifferentiated cells to the site of injury and to stimulate growth. Another component of the platelets, stromal cell derived factor ILFA causes cells to obtain neuererire area.
Furthermore, when used with stem cells from bone marrow of the patient, PRP "Veröffentlichunts "of stem cells that are multiplying rapidly. This inflammation is the driving force for the process of healing.
Parautilizar an analogy, the PRI, particularly when used in combination with stem cells, involved in the process of healing "guerrap units.
PRP should be prepared to ensure maximum cAntida platelets with a high concentration effect of growth factors. Of course, the more growth can be delivered to the site of the lesion, ensto likely it is the healing of tissue.
Regenerative this approach is diametrically opposed to the traditional method of healing tissue, was non-steroidal anti-inflammatory drugs and injections of steroids, which, while inflamed réduisant, égalementn impeded the healing process.
PRP is often used in combination with percutaneous tenotomY. This is an irritation, if the needle into the affected area using ultrasound guidance after PRP injectionslowly into the page.
The use of diagnostic ultrasound has revolutionized the musculoskeletal field of medicine for the healing of tissues and tenotomy procedure often requires an intervention chirurgicalesment its morbidity and mortality. To ensure that the successful use of PRP and / or stem cell engineering in tissue engineering, it is essential that the diagnosis of ultrasound to the "sticks" and the placement of the PRP.
PRP is readyt by 20 CC of the patient's blood, then the blood in a centrifuge that the level of platelets. These 20 cc of whole blood yields about 2-10 inch plasma rich in targattes.
Contraindications for the application of PRP are platelet dysfunction, low platelet count, infections, anemia.
The number IGott of treatment is two to three separate four to eight weeks. The need for further treatment may be with Doppler ultrasound, to see wIf the area remains inflamed (good) or "cold" (bad).
Before PRP procedure, no need for a patient Tenir saroideos unNTI medication for at least 3-4 days. May return a week later. In addition, patients with rheumatoid arthritis should be methotrexate for his pastures, or a week before and one week after the surgery. Biological medicines patients need more medication for his time, especially when it comes to adalimumab (Humira) and infliximab (Remicade) because of the long half-life of this drug.
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