Saturday, April 11, 2009

Two genetic variants in Caucasians responsible male pattern baldness

In a joint study from McGill University, King's College London and GlaxoSmithKline Inc. The researchers have two genetic variants in Caucasians that together account for seven times higher risk for hair loss in men.
With regard to hair loss in men, it is estimated that one third of all men are affected at the age of 45, have an impact on the social and economic. Global chiffresest to show that the treatment of male doctorn baldness recently surpassed $ 405 million worldwide, while the cost for hair transplantation in the United States about $ 115 million (U.S.) in 2007. Androgenic alopecia is the most common form of hair loss in men, if you have your hair in a well-defined in the first few days, with a distinctive M-shaped hairline. Moreover, it is estimated that 80% of cases are hereditary. Dr. Vincent Moose GlaxoSmithKline, Dr. Brent Richards of McGill Universitysity, Faculty of Medicine and the affiliated Jewish General Hospital (and before the King's College) and Dr. Tim Spector of King's College, with colleagues in Iceland, Switzerland and the Netherlands, a genome-wide association of white men in 1125, estimated to hair loss in men. In the study, two auparavantte unknown genetic variants on chromosome 20, which significantly increases the risk of hair loss in men. These results help to confirm the  Results of the 1650 white men.

Richards, Professor of Genetic Epidemiology, said that, so it can be assumed that the same genetic variation may be the cause of hair loss in men, not white. However, this argument can not be demonstrated by the study toutSelon in these populations.

Although the results of this survey ere called science, which does not say that about treatment or cure for baldness in uMmen in the near future. Richards has also considered that a single case was detected and the treatment of hair loss in men, the further research. However, premièrepremier researchers has succeeded in the obstacle, as the treatment of a disease can not be made until the case has been identified.

Spector from King's College and director of the study cohort TwinsUK, adding that predicting the future of hair loss before LGold presence in de -n the month of May, which meant that some therapies are effective treatment of late stage hair loss.

Furthermore, Richards said that the investigators knew Deuna variant gene on the X chromosome, which is associated with hair loss in men over a long period.

He also said that because of the volontàalternativa gene on chromosome X, it is assumed that baldness is inherited from the mother of the family. But, nothing is easier Jackea, and foundthat the gene, but many genes are the cause for hair loss in men. Until recently, these other genes were identified. Therefore, if both the risk variants on chromosome 20 and without the knowledge of the variation of the X chromosome is present, the risk run, and soon the seven-fold increase.

Encorepiù surprising is that 14% of the total population, ie one in seven men with two variants of the risks.

No comments: